Dear Customer,
Since we do not ever install this motherboard in the Titan 2.0 case,
So we are not 100% sure if it is compatible or not.
As we know, many AM5 or 13th motherboard is not compatible.
But if it is not compatible, you can use a longer tube or extender to connect the CPU water block. It depends on the distance between the CPU and distro plate.
You can try your current tubes and find out the distance.
And then you can choose the correct extender.
When you use the Titan CPU water block with the screws kit BP-CPUPDB-AMD5MS,It fits AM5.
Here are the links. They are on sale now.
If you have any questions, feel free to contact us.
https://www.newegg.com/p/2YM-0001-008N9?item=9SIAEMWJ9X7313
https://www.newegg.com/p/37B-000X-00537?item=9SIAEMWHE50010